Simon M. reported that compiled rts/Updates.cmm on x86-64 with the LLVM backend produced some pretty bad code. The ncg produces this:

stg_upd_frame_info:
.Lco:
       movq 8(%rbp),%rax
       addq $16,%rbp
       movq %rbx,8(%rax)
       movq $stg_BLACKHOLE_info,0(%rax)
       movq %rax,%rcx
       andq $-1048576,%rcx
       movq %rax,%rdx
       andq $1044480,%rdx
       shrq $6,%rdx
       orq %rcx,%rdx
       cmpw $0,52(%rdx)
       jne .Lcf
       jmp *0(%rbp)
.Lcf:
       [...]

The LLVM backend produces this though:

stg_upd_frame_info:                     # @stg_upd_frame_info
# BB#0:                                 # %co
       subq    $104, %rsp
       movq    8(%rbp), %rax
       movq    %rax, 24(%rsp)          # 8-byte Spill
       movq    %rbx, 8(%rax)
       mfence
       movq    $stg_BLACKHOLE_info, (%rax)
       movq    %rax, %rcx
       andq    $-1048576, %rcx         # imm = 0xFFFFFFFFFFF00000
       andq    $1044480, %rax          # imm = 0xFF000
       shrq    $6, %rax
       addq    %rcx, %rax
       addq    $16, %rbp
       cmpw    $0, 52(%rax)
       movsd   %xmm6, 88(%rsp)         # 8-byte Spill
       movsd   %xmm5, 80(%rsp)         # 8-byte Spill
       movss   %xmm4, 76(%rsp)         # 4-byte Spill
       movss   %xmm3, 72(%rsp)         # 4-byte Spill
       movss   %xmm2, 68(%rsp)         # 4-byte Spill
       movss   %xmm1, 64(%rsp)         # 4-byte Spill
       movq    %r9, 56(%rsp)           # 8-byte Spill
       movq    %r8, 48(%rsp)           # 8-byte Spill
       movq    %rdi, 40(%rsp)          # 8-byte Spill
       movq    %rsi, 32(%rsp)          # 8-byte Spill
       je      .LBB1_4

This has two main problems:

1. mfence instruction (write barrier) isn't required. (write-write barriers aren't required on x86)
2. LLVM backend is spilling a lot of stuff unnecessarily.

Both these I think are fairly easy fixes. LLVM is handling write barriers quite naively at the moment so 1. is easy. The spilling problem I think is related to a previous fix I made where I need to explicitly kill some of the stg registers if they aren't live across the call, otherwise LLVM rightly thinks they are live since I always pass the stg registers around (so live on entry and exit of every function unless I kill them).